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Webinar: Spatial organization of multicellular immune hubs in MMRd and MMRp colorectal cancer


Now Available On-Demand!

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors.
 
To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from human colorectal tumors. Analysis revealed extensive transcriptional and spatial remodeling across tumors. To discover hubs of interacting malignant and immune cells, we identified expression programs in different cell types that co-varied across tumors from affected individuals and used spatial profiling to localize coordinated programs.
 
By identifying interacting cellular programs, we reveal the logic underlying spatially organized immune-malignant cell networks.


Speaker
 
Dr-Jon-Chen.jpg
Jonathan Chen, M.D., Ph.D.
Instructor - Department of Pathology at Massachusetts General Hospital
Director - MGH Cancer Center Immuno-Oncology Biomarker Lab (IOBL)

Immuno-oncology imagery.

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